8 million grant to study gender variations in antidepressant effects
Tallahassee, fla.In low amounts, the reccommended anesthetic drug ketamine works
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antidepressant, and for ladies the boost in mood is easier to achieve. A florida
state university college of drugs researcher is learning more about why this
drug, used as an antidepressant going back decade, requires a higher dosage to
extend depression in males. Mohamed kabbaj, a professor in the department of
biomedical sciences at the faculty of medicine, were given a $1.8 million grant
from the nation's Institute of Mental Health to support his research. "The first
purpose is to show the molecular mechanism behind the endocrine system estrogen
and progesterone that are enhancing the effect of ketamine in females, kabbaj
recounted. "The other purpose of the grant is to detect whether males will
respond to estrogen and progesterone in addition to ketamine administered at a
low dose, Researchers would like to looking for ways around giving higher doses
of ketamine to males because of the drug's side effects. "At methods and high
doses, ketamine can create dissociation from one's area, kabbaj referred to. "It
is an addictive drug, and you cannot give it constantly, Administering ketamine
with a variety estrogen and jordans shoes for women progesterone,
for abundant in females, may diminish a few side effects.Kabbaj and his team
continue investigating ketamine despite its side effects automobile quick
antidepressant response time. "Ketamine is used as an antidepressant in clinics
now because it becomes effective acutely, kabbaj assumed. "Two working a lot of
time after one low dose, daily life feel better.The classic mao inhibitors take
two to three weeks to work, This speedy, low dose result can be a lifesaver for
suicidal patients whose repeated thoughts of harming themselves make time a
precious commodity.It is also used choice to electroconvulsive shock therapy,
which depressive patients instances refuse. But kabbaj's research shows that
gender differences must be considered. "Even with classic mao inhibitors there
are studies showing that men and women respond differently to different classes
of antidepressant drugs, kabbaj described. "Their brains will vary, so we must
find out if there are treatments that work better in women and treatments that
work better in men, Kabbaj wants to know whether striking the best balance
between ketamine, progesterone and estrogen in both genders permits safer use of
ketamine as an ongoing treatment for depression, so that it can treat those in
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4 of immediate relief from depression without the side effects.
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