2014年2月26日星期三

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8 million grant to study gender variations in antidepressant effects Tallahassee, fla.In low amounts, the reccommended anesthetic drug ketamine works nike:http://www.mowi2.com/ as an antidepressant, and for ladies the boost in mood is easier to achieve. A florida state university college of drugs researcher is learning more about why this drug, used as an antidepressant going back decade, requires a higher dosage to extend depression in males. Mohamed kabbaj, a professor in the department of biomedical sciences at the faculty of medicine, were given a $1.8 million grant from the nation's Institute of Mental Health to support his research. "The first purpose is to show the molecular mechanism behind the endocrine system estrogen and progesterone that are enhancing the effect of ketamine in females, kabbaj recounted. "The other purpose of the grant is to detect whether males will respond to estrogen and progesterone in addition to ketamine administered at a low dose, Researchers would like to looking for ways around giving higher doses of ketamine to males because of the drug's side effects. "At methods and high doses, ketamine can create dissociation from one's area, kabbaj referred to. "It is an addictive drug, and you cannot give it constantly, Administering ketamine with a variety estrogen and jordans shoes for women progesterone, for abundant in females, may diminish a few side effects.Kabbaj and his team continue investigating ketamine despite its side effects automobile quick antidepressant response time. "Ketamine is used as an antidepressant in clinics now because it becomes effective acutely, kabbaj assumed. "Two working a lot of time after one low dose, daily life feel better.The classic mao inhibitors take two to three weeks to work, This speedy, low dose result can be a lifesaver for suicidal patients whose repeated thoughts of harming themselves make time a precious commodity.It is also used choice to electroconvulsive shock therapy, which depressive patients instances refuse. But kabbaj's research shows that gender differences must be considered. "Even with classic mao inhibitors there are studies showing that men and women respond differently to different classes of antidepressant drugs, kabbaj described. "Their brains will vary, so we must find out if there are treatments that work better in women and treatments that work better in men, Kabbaj wants to know whether striking the best balance between ketamine, progesterone and estrogen in both genders permits safer use of ketamine as an ongoing treatment for depression, so that it can treat those in need Air Jordan 4 of immediate relief from depression without the side effects.


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